Protein Details: Potassium channel subfamily K member 7

Protein ID

ICDB_Pro_1733

Protein Name

Potassium channel subfamily K member 7

Gene Name

Kcnk7; Dpkch3; Kcnk6; Kcnk8; Knot1

Organism

Mus musculus (Mouse)

Length

307 amino acids

AlphaFoldDB

AF-Q9Z2T1-F1-model_v4.pdb

Function

Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.

Sequence

MGSLKPWARYLLLLMAHLLAMGLGAVVLQALEGPPARHLQAQVQAELASFQAEHRACLPPEALEELLGAVLRAQAHGVSSLGNSSETSNWDLPSALLFTASILTTTGYGHMAPLSSGGKAFCVVYAALGLPASLALVAALRHCLLPVFSRPGDWVAIRWQLAPAQAALLQAAGLGLLVACVFMLLPALVLWGVQGDCSLLEAIYFCFGSLSTIGLGDLLPAHGRGLHPAIYHLGQFALLGYLLLGLLAMLLAVETFSELPQVRAMVKFFGPSGSRTDEDQDGILGQDELALSTVLPDAPVLGPTTPA

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Detected in embryo; eye; lung and liver. Weakly expressed in colon; testis; atria; kidney; intestine; bladder; uterus; ovary; salivary gland; thymus and brain stem. Not detected in brain; cerebellum; spinal cord; heart; ventricle; skeletal muscle; liver; placenta and pancreas. Not detected in brain; cerebellum; spinal cord; heart; ventricle; skeletal muscle; liver; placenta and pancreas. Not detected in brain; cerebellum; spinal cord; heart; ventricle; skeletal muscle; liver; placenta and pancreas. In the eye; highly expressed in the retinal ganglion cell layer and inner nuclear layer

DOI ID

10.1074/jbc.274.17.11751

RefSeq

NP_034739.2